Targeting Dimethylarginine Dimethylaminohydrolases in Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Targeting dimethylarginine dimethylaminohydrolases in pulmonary arterial hypertension: a new approach to improve vascular dysfunction?
Pulmonary arterial hypertension (PAH) is a devastating and life-threatening clinical syndrome characterized by elevated pulmonary artery pressures leading to progressive symptoms, including shortness of breath, fatigue, and a decline in functional ability. The hemodynamic definition of PAH is a mean pulmonary artery pressure of 25 mm Hg at rest or 30 mm Hg during exercise, with a normal pulmona...
متن کاملAsymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension.
OBJECTIVE We explored the potential role of the endogenous NO synthase inhibitor asymmetrical dimethylarginine (ADMA) in patients with idiopathic pulmonary arterial hypertension (IPAH). Method and Results- We correlated plasma ADMA levels and cardiovascular indices from right heart catheterization in 57 patients with IPAH. Predictors of survival in patients with IPAH were studied. Furthermore, ...
متن کاملTargeting Neurohormonal Activation in Pulmonary Arterial Hypertension
SEE PAGE 22 P ulmonary artery hypertension (PAH) is an angioproliferative disorder of the lung circulation that results in a heart failure syndrome with a grim prognosis (1). Similar to other forms of left ventricular failure, right ventricular failure (RVF) is progressive and largely incurable unless the primary cause can be eliminated (i.e., lung transplantation for PAH). Although pressure ov...
متن کاملTargeting cell motility in pulmonary arterial hypertension.
Pulmonary artery smooth muscle cells (PASMC), in pulmonary arterial hypertension (PAH), contribute to obliterative vascular remodelling and are characterised by enhanced proliferation, suppressed apoptosis and, a much less studied, increased migration potential. One of the major proteins that regulate cell migration is focal adhesion kinase (FAK), but its role in PAH is not fully understood. We...
متن کاملTHE EFFECTS OF CAPTOPRIL ON PULMONARY AND SYS TEMIC ARTERIAL PRESSURES IN HIGHALTITUDE PULMONARY HYPERTENSION
The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.110.017038